Cardiology Is Flow

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Cardiology is flow.

Cardiology is about flow. The primary purpose of the cardiovascular system is to drive, control, and maintain blood flow to all parts of the body. Flow dictates the form and function of the heart and blood vessels through ontogenic and phylogenic development, the structural and functional consequence of repair, and in its end stages, remodeling and response to failure. Flow should therefore be ...

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Background—Upregulated by atheroprotective flow, the transcription factor Krüppel-like factor 2 (KLF2) is crucial for maintaining endothelial function. MicroRNAs (miRNAs) are noncoding small RNAs that regulate gene expression at the posttranscriptional level. We examined the role of miRNAs, particularly miR-92a, in the atheroprotective flow–regulated KLF2. Methods and Results—Dicer knockdown in...

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ژورنال

عنوان ژورنال: Circulation

سال: 2006

ISSN: 0009-7322,1524-4539

DOI: 10.1161/circulationaha.106.632687